William Smith, not to be confused with Scottish-born lithographer William L. Smith, operated a print shop on the 700 block of South Third Street in Philadelphia ca. 1860-ca. 1891. Originally listed as a picture framer maker in city directories beginning in 1856, Smith published and distributed genre, historical, religious, and portrait lithographs and chromolithographs beginning ca. 1860 from 264, later 706, South Third Street (listed address 1856-1862) and 702 South Third Street (listed address 1863-1891). Smith was also listed at 33 South 6th Street in 1868 and 1890.

Noted lithographs distributed by Smith include "Death of George Shiffler" (ca. 1844-1860); "Washington's Triumphal Entry into New York, Nov. 25th, 1783" printed by P.S. Duval & Son; and the double-sided "Protest Against the British Government" containing a commemorative design in honor of radical Robert Emmett on one side and a portrait of a girl on the other side, possibly as a camouflage.